Human Growth Hormone (HGH)
A hormone which stimulates growth in animals or plants is known as growth hormones. In human beings, the growth hormone is secreted by pituitary glands. Somatotropin is another name for growth hormone; the human growth hormone is abbreviated as Human Growth Hormone (HGH). It is a hormone which is thought to speed up the growth at cellular level in the body, besides, cellular regeneration is also another activity carried out by this hormone. The Human Growth Hormone (HGH) is a single chain of polypeptide containing 191-amino acid which is prepared and stored in somatotropic cells. The latero-anterior parts of pituitary glands are responsible for its secretion.
The somatropin is a recombinant hormone which is primarily used in certain drugs to overcome growth related issues in kids and adults. Doctors prescribe this substance to the people who are found to have a deficiency of Human Growth Hormone. It is a complex hormone; it is believed that some of its functions are yet to be discovered. Hence it is recommended to use HGH only under the doctor’s prescription.
Use of Human Growth Hormone for Sports:
Initially, human growth hormones were used to increase muscular strength and stamina by some sportsmen, the tests like traditional urine analysis do not detect the probable doping with Human Growth Hormone, but now days, and several advanced tests could confirm its presence in the blood. FDA has not approved the use of such performance enhancers during sports and mega events.
Regulation of Human Growth Hormone:
The production of growth hormones in the pituitary gland situated at the base of fore brain is regulated by several neuro-secretory cells of hypothalamus. The growth hormones which are released by anterior pituitary gland are affected directly by certain factors which are also termed as stimulators. The principal stimulators include nutrition, physical activity and sleep. On the other hand, several factors are inhibitory as well, free fatty acids for example are considered to be inhibitory for the secretion of growth hormones. There are some other associated factors which can directly affect the secretion of growth hormones, these include age, sleep, diet, sex, physical activity, stress etc.
The teenagers are supposed to have almost 700 μg/day of growth hormone. While the adults over 20 years of age are supposed to have 400 μg/day of growth hormone in their blood. It is very significant to note that when a person is deprived of sleep, the release of growth hormone is inhibited. Hence, sleep is an important factor when human growth is considered.
Stimulators of Human Growth Hormone (HGH):
There are certain factors which are considered to speed up or stimulate the production of growth hormones, such factors include:
- Peptide hormones known as somatocrinin are responsible for combining the GH releasing hormone receptor.
- Ghrelin via binding another hormone associated with growth known as secretagogue receptors.
- Sex hormones like androgens and estrogens in increased production are also stimulators of growth hormones. Hence growth is maximum at the age of puberty as there is an increased secretion of Human Growth Hormone during this time.
- Hypoglycemia, the low level of sugar in the blood, arginine as well as propranolol.
- Deep sleep
- Niacin also known as nicotinic acid or Vitamin B3.
- Physical activity.
Inhibitors of Human Growth Hormones:
On the other hand, there are certain factors which produce negative effect on the production of human growth hormones. Such factors are called inhibitory as these include:
- Hyperglycemia which is a condition where blood sugar is high in the body.
- Glucocorticoids, which are group of which are involved in the metabolism of carbohydrates, proteins, and fats and have anti-inflammatory activity.
- Dihydrotestosterone, which is is a sex steroid and androgen hormone.
Functions of Human Growth Hormone:
Human Growth Hormone has variety of functions to perform in a body. Some of the key functions carried out by Human Growth Hormone (HGH) include:
- Increasing height in children as well as adults.
- Promoting bone and cartilage health in human adults.
- The human growth hormone also helps in the retention of calcium which indirectly strengthens the bones and other calcium containing substances in the body like cartilages and teeth.
- It promotes the breakdown of fats in the body into fatty acids, the process is known as lipolysis.
- The secretion of Human Growth Hormone is considered to be responsible for the increase in muscle mass as well and this is done via sarcomere hypertrophy.
- Increased protein metabolism is also one of the key actions of Human Growth Hormone in our bodies.
- Human Growth Hormone is responsible of maintenance of certain ongoing physiological processes, the condition is known as homeostasis.
- With exception to brain, it stimulates the growth and regeneration of all other internal organs of the body.
- The level of glucose uptake by liver is reduced.
- Islets of langerhans in pancreas which are thought to release insulin are also under the control of Human Growth Hormone (HGH).
- Human Growth Hormone is also essential for healthy immune system.
- Human Growth Hormone is also responsible for healthy functioning of thyroid glands.
Impact of High HGH in Human Body:
The increased quantity of HGH however can be a cause of certain ailments in the body. Muscle weakness, resistance to insulin, type 2 diabetes, reduced or abnormal sexual function, carpal tunnel syndrome are few conditions which are caused when the body has high Human Growth Hormone level. When a person is in 50’s, the high Human Growth Hormone (HGH) can also cause tumor formation in some parts of the body.
Impact of Low HGH in Human Body:
On the other extreme, the low level of HGH in the body can be disastrous as well. The deficiency of HGH can occur at any age. Short stature due to growth failure is often related to Human Growth Hormone deficiency in the body. Another effect of HGH deficiency is delay in sexual maturity. It is rare for adults to suffer from Human Growth Hormone deficiency, but if they suffer from such concerns, pituitary adenoma, lesions and idiopathic GHD are often reported.
Some adults with low Human Growth Hormone (HGH) in their bodies tend to have high mass of fats, lower muscular mass and low energy level in the body. All these conditions are linked with quality of life one leads. Read more about HGH Supplements and Subscribe if you like our article.